Opana ER 10 mg (oxymorphone hydrochloride extended-release) is a powerful prescription opioid analgesic used to manage severe chronic pain that requires long-term, around-the-clock opioid treatment and cannot be managed with other medications. The "ER" in its name stands for extended-release, which means the drug is formulated to release the active ingredient gradually over a 12-hour period, providing sustained pain relief.